Where did Herpes Come From?

On June 13, 2014, in Blog, Education, FAQ, by Admin

A lot of websites claim herpes is a few thousand years old.  That’s not when herpes came about; that’s when writing things down came about, so that’s the first time it actually got documented.  We’ve had Herpes Simplex much, much longer than that – more than a million and a half years longer for HSV-2and 6 million years  for HSV-1.

Many articles will claim the herpes simplex jumped from chimpanzees to humans (as you can see below, even the research study mentions humans).  This isn’t exactly true, either.  Humans as we know them – Homo Sapiens – didn’t even exist until 100,000 years ago, 1.5 million years after the more recent (HSV-2) jump occurred.

The jump occurred between the ancestors of chimpanzees and our own evolutionary ancestors, Homo Erectus; the first primates to get down out of the trees, walk upright and discover fire. So, it’s safe to say that humans didn’t acquire herpes simplex; herpes simplex inherited us. [All indications are that this is likely true for the remaining 7 human herpesviruses, too.]

From UCSD… Date: June 10, 2014


Herpes Infected Humans Before They Were Human

The virus originated in chimpanzees, jumping into humans 1.6 million years ago

Researchers at the University of California, San Diego School of Medicine have identified the evolutionary origins of human herpes simplex virus (HSV) -1 and -2, reporting that the former infected hominids before their evolutionary split from chimpanzees 6 million years ago while the latter jumped from ancient chimpanzees to ancestors of modern humans – Homo erectus– approximately 1.6 million years ago. The findings are published in the June 10 online issue of Molecular Biology and Evolution.

“The results help us to better understand how these viruses evolved and found their way into humans,” said Joel O. Wertheim, PhD, assistant research scientist at the UC San Diego AntiViral Research Center and lead author of the study. “Animal disease reservoirs are extremely important for global public health. Understanding where our viruses come from will help guide us in preventing future viruses from making the jump into humans.”

Approximately two-thirds of the human population is infected with at least one herpes simplex virus. The viruses are most commonly presented as cold sores on the mouth or lips or blisters on the genitals. “Humans are the only primates we know of that have two herpes simplex viruses,” said Wertheim. “We wanted to determine why.”

The researchers compared the HSV-1 and HSV-2 gene sequences to the family tree of simplex viruses from eight monkey and ape host species. Using advanced models of molecular evolution, the scientists were able to more accurately estimate ancient viral divergence times. This approach allowed them to determine when HSV-1 and HSV-2 were introduced into humans with far more precision than standard models that do not account for natural selection over the course of viral evolution.

The genetics of human and primate herpes viruses were examined to assess their similarity. It became clear that HSV-1 has been present in humans far longer than HSV-2, prompting the researchers to further investigate the origins of HSV-2 in humans. The viral family tree showed that HSV-2 was far more genetically similar to the herpes virus found in chimpanzees. This level of divergence indicated that humans must have acquired HSV-2 from an ancestor of modern chimpanzees about 1.6 million years ago, prior to the rise of modern humans roughly 200,000 years ago.

“Comparing virus gene sequences gives us insight into viral pathogens that have been infecting us since before we were humans,” said Wertheim.


Co-authors include Martin D. Smith and Sergei L. Kosakovsky Pond, UC San Diego; Davey M. Smith, UC San Diego and Veterans Affairs San Diego Healthcare System; Konrad Scheffler, UC San Diego and Stellenbosch University, South Africa.

Funding for this research came from the University of California Laboratory Fees Research Program (grant 12-LR-236617), the National Institutes of Health (grants DA034978 and GM093939), the Bioinformatics and Information Technologies Core of the UC San Diego Center for AIDS Research (P30 AI036214), and the Department of Veterans Affairs.

Media contacts: Scott LaFee, 619-543-6163, ; Joshua Romero, 619-471-3884, 

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